Pathogen sensing in systemic inflammatory disease

免疫反应的启动、扩增和猝灭是一个精心策划的过程，可以消除入侵的病原体，同时最大限度地减少对宿主组织的附带损害。这项研究的重点是限制免疫反应的蛋白质，以预防炎症性疾病，如类风湿关节炎、牛皮癣和炎症性肠病。这项工作还将探索钾通道在感染期间保护宿主免受器官衰竭的作用，通过耦合免疫反应的能量需求和器官功能。这可能对脓毒症的管理具有重要意义，脓毒症是一种与感染相关的全身免疫反应，是危重患者死亡的主要原因。

The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel disease. This work will also explore the role of a potassium channel that protects the host from organ failure during an infection, by coupling the energy requirements of mounting an immune response, and organ function. This may have important implications for the management of sepsis, a systemic immune response associated with infection and the leading cause of death in critically ill patients.