Remote control of nanoparticle biodistribution

这项国际合作的目的是重组纳米医学和表面科学领域的专家，以解决阻碍纳米颗粒技术转化为临床环境的突出科学挑战。在这个项目中，我们建议研究高频声波对NPs命运的影响，特别是它们的生物分布。因此，该项目的主要目标是研究超声辐射对生物介质中NPs-细胞相互作用的影响，并确定超声特性如何控制NPs的生物分布、毒性和治疗效果。通过这次合作，我们的目标是结合一套独特的物理化学和生物学表征技术，这将使我们能够阐明超声波对NPs本身以及它们与不同生物实体（如蛋白质和细胞）相互作用的影响。从这次合作中获得的知识将促进进一步的研究，旨在阐明，最重要的是预测，基于纳米药物的物理化学性质的生物学命运。

The purpose of this international collaboration is to regroup experts in the fields of nanomedicine and surface sciences to tackle outstanding scientific challenges hampering nanoparticle technologies translation to clinical settings. In this project, we propose to study the impact of high frequency acoustic waves on NPs fate and particularly their biodistribution. The main objective of the project is thus to study the impact of ultrasound radiation on NPs-cell interactions in biological media and to establish how ultrasound properties could govern biodistribution, toxicity and therapeutic efficacy of NPs. Through this collaboration we aim to combine a unique set of physicochemical and biological characterization techniques that will allow us to elucidate the effect of ultrasounds both on the NPs themselves and on their interaction with different biological entities such as proteins and cells. The knowledge gained from this collaboration will nurture further studies aimed to elucidate, and most importantly predict, the biological fate of nanomedicine based on their physicochemical properties.