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Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity

Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity
药理学伴侣作用的分子机制和结构决定因素；
批准号：
478493
负责人：
Bouvier Michel
金额：
$64.09万
依托单位：
Institute for Research in Immunology and Cancer (Montreal, QC)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478493&lang=en
关键词：
Conformational Diseases Drug Discovery G Protein-Coupled Receptors Genetic Diseases Inherited Diseases Melanocortin Type 4 Receptor Obesity Pharmacological Chaperones Protein Folding Protein Trafficking

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中文摘要
翻译
由基因突变引起的蛋白质错误折叠是被称为构象疾病的遗传性疾病的常见原因。由于G蛋白偶联受体（gpcr）参与了大多数生理功能，这种成员的突变很大
英文摘要
Misfolding of proteins resulting from genetic mutations is a frequent cause of inherited diseases known as conformational diseases. Since G protein-coupled receptors (GPCRs) are involved in most physiological functions, mutations of members of this large
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会议论文
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G protein functional selectivity in metabolic disorders
A novel paradigm for effective and safer treatment of schizophrenia: biased (ant)agonists with a characterized polypharmacological profile
Assembly, trafficking and regulation of G protein-coupled receptor signaling complexes
  • 批准号：
    344989
  • 项目类别：
    Operating Grants
  • 资助金额：
    $88.83万
  • 财政年份：
    2016
  • 负责人：
    Bouvier Michel
  • 依托单位：
    Universit de Montral
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