Development of clinical candidate hypoxia-activated DNA-PK inhibitors
Development of clinical candidate hypoxia-activated DNA-PK inhibitors
批准号:
490356
负责人:
Minchinton Andrew I
金额:
$71.33万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2027-09-01
中文摘要
放疗和化疗仍然是治疗不能手术的癌症的主要方法。这些疗法会杀死癌细胞,但有些癌细胞由于其修复DNA损伤的能力而具有抗性。最近,可以阻断癌细胞生长的药物,
英文摘要
Radiation and chemotherapy remain the principal treatments for inoperable cancers. Cancer cells are killed following these therapies, but some are resistant due to their ability to repair the DNA damage. Recently, drugs that can block a cancer cell's abil
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会议论文
FLASH radiotherapy - mechanisms and translational studies
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批准号:444863
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项目类别:Operating Grants
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资助金额:$66.88万
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财政年份:2021
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负责人:Minchinton Andrew I
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依托单位:
Metabolic manipulation of hypoxia for improved radiotherapy response
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批准号:451372
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资助金额:$49.32万
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负责人:Minchinton Andrew I
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依托单位:
Hypoxia-activated DNA repair inhibitors to improve cancer therapy
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批准号:403718
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资助金额:$41.8万
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财政年份:2019
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负责人:Minchinton Andrew I
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依托单位:
Hypoxia-selective inhibitors of DNA repair
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批准号:376328
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项目类别:Operating Grants
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资助金额:$18.9万
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财政年份:2017
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负责人:Minchinton Andrew I
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依托单位:
Metabolic manipulation of hypoxia and radiotherapy response
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批准号:293382
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项目类别:Operating Grants
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资助金额:$52.97万
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财政年份:2013
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负责人:Minchinton Andrew I
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依托单位:
Microenvironmental strategies for the optimal utilization of anti-angiogenic drugs combinations
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批准号:240119
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项目类别:Operating Grants
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资助金额:$48.27万
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财政年份:2011
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负责人:Minchinton Andrew I
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依托单位:
Hypoxia-selective radiation sensitizers
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批准号:171879
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项目类别:Operating Grants
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资助金额:$40.81万
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财政年份:2008
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负责人:Minchinton Andrew I
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依托单位:
海外基金