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Role of the mTOR/S6K1 and RSK pathways in the pathogenesis of insulin resistance

Role of the mTOR/S6K1 and RSK pathways in the pathogenesis of insulin resistance
mTOR/S6K1 和 RSK 通路在胰岛素抵抗发病机制中的作用
批准号:
201730
负责人:
Marette Andr
金额:
$69.81万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2010
资助国家:
加拿大
项目状态:
已结题
起止时间:
2010-03-01 至 2015-03-01

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中文摘要
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英文摘要
This CIHR-funded project has focused on the potential role of the mTORC1/S6K1 signaling pathway in the induction of insulin resistance for glucose metabolism in insulin target cells and tissues. We found that IRS-1 Ser phosphorylation by mTORC1 and S6K1 i
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Nutrient sensing mechanisms underlying the metabolic effects of dietary proteins in obesity and type 2 diabetes
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    $54.62万
  • 财政年份:
    2023
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Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt
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Host iNOS dictates gut dysbiosis, bacterial translocation and tissue insulin resistance in murine and human obesity
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    $59.35万
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    2021
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Microbiome and liver mechanisms underlying the impact of dietary proteins on obesity and insulin resistance
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    456675
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  • 依托单位:
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