The role and molecular mechanism of Sonic hedgehog in neural circuit formation

Sonic Hedgehog在神经回路形成中的作用及分子机制

• 批准号: 201466
• 负责人: Charron Frederic
• 金额: $ 60.98万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2015-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=201466&lang=en
• 关键词: Axon Guidance; Genetics; Hedgehog; Mouse; Nervous System Development; Signal Transduction; Spinal Cord

The brain is composed of billions of interconnected neurons. To correctly form neuronal circuits, the developing axons (a long extension of a neuron) require attractive and repulsive molecules to lead them to their appropriate targets. One such molecule i

大脑由数十亿个相互连接的神经元组成。为了正确形成神经元回路，正在发育的轴突（神经元的长延伸）需要吸引和排斥的分子来引导它们到达适当的目标。一个这样的分子我