Hedgehog signaling and medulloblastoma tumorigenesis

Hedgehog 信号传导与髓母细胞瘤肿瘤发生

• 批准号: 255536
• 负责人: Charron Frederic
• 金额: $ 52.01万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=255536&lang=en
• 关键词: Cerebellum; Genetics; Hedgehog; Medulloblastoma; Mouse; Patched1; Signal Transduction

Medulloblastoma is a very aggressive childhood cerebellum cancer and the most common brain tumor in children. One of the important causes of medulloblastoma is aberrant activation of the Sonic hedgehog (Shh) signaling pathway. Our lab recently identified

髓母细胞瘤是一种非常具有侵袭性的儿童小脑肿瘤，也是儿童最常见的脑肿瘤。神经管母细胞瘤的重要原因之一是Sonic hedgehog（Shh）信号通路的异常激活。我们的实验室最近发现