Neuronal functions of the microtubule-associated protein tau in development and ageing

微管相关蛋白 tau 在发育和衰老过程中的神经元功能

• 批准号: DP1096491
• 负责人: Prof Jürgen Götz
• 金额: $ 38.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-02-03 至 2013-02-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096491
• 关键词: Neuronal; functions; microtubule; associated; protein

The project uses a combination of transgenic mouse strains characterised by neurodegeneration and senescence-accelerated (SAM) mice, to determine the first steps of the aggregation of the protein tau in degenerating neurons, how absence of tau protects from brain atrophy, and in which physiological processes tau is involved. This project provides the biological foundation for a tau-based therapy of senescence-associated conditions. It provides the biological foundation for developing effective therapies for human neurodegenerative conditions, by preventing tau aggregation and phosphorylation. We will patent new data and expand our existing links to Australian biotech and international pharmaceutical companies.

该项目使用以神经变性和衰老加速（SAM）小鼠为特征的转基因小鼠品系的组合，以确定蛋白质tau在变性神经元中聚集的第一步，tau的缺失如何防止脑萎缩，以及tau参与了哪些生理过程。该项目为基于tau的衰老相关疾病治疗提供了生物学基础。它通过防止tau聚集和磷酸化，为开发人类神经退行性疾病的有效疗法提供了生物学基础。我们将为新数据申请专利，并扩大与澳大利亚生物技术公司和国际制药公司的现有联系。