Nuclear functions of the microtubule-associated protein tau

微管相关蛋白 tau 的核功能

• 批准号: DP130101932
• 负责人: Prof Jürgen Götz
• 金额: $ 21.32万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP130101932
• 关键词: Nuclear; functions; microtubule; associated; protein

The important neuronal protein, tau, has cellular functions that go far beyond its established role in stabilising microtubules. This project will determine which tau species are nuclearly localised, what the consequences are for nuclear functions, and how phosphorylation regulates this localisation.

重要的神经元蛋白tau具有远远超出其稳定微管的既定作用的细胞功能。该项目将确定哪些tau物种是核定位的，核功能的后果是什么，以及磷酸化如何调节这种定位。