Novel cellular functions of the microtubule-associated protein tau: Physiological and pathological implications

微管相关蛋白 tau 的新细胞功能：生理学和病理学意义

• 批准号: DP0773577
• 负责人: Prof Jürgen Götz
• 金额: $ 31.2万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-03-05 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773577
• 关键词: Novel; cellular; functions; microtubule; associated

The social and economic burden of Alzheimer's disease (AD) is enormous, and by 2040 more than 500,000 Australians will suffer from this disease. A key histopathological hallmark of this and many other related diseases are insoluble deposits of the protein tau. Research into novel functions of tau in signalling and transport (both of which are heavily compromised in diseased brains) will be followed directly by assay development for tau-directed drug screening. The national benefit of this research is manifold by (a) patenting new data, (b) developing treatment strategies for an un-curable disease, and (c) establishing links to the growing Australian biotech industry (in addition to existing links to international pharmaceutical companies).

阿尔茨海默病（AD）的社会和经济负担是巨大的，到2040年，将有超过50万澳大利亚人患有这种疾病。这种疾病和许多其他相关疾病的一个关键的组织病理学标志是蛋白tau的不溶性沉积。研究tau在信号传导和运输中的新功能（这两种功能在患病大脑中都严重受损）将直接用于tau定向药物筛选的检测开发。这项研究的国家利益是多方面的：(a)为新数据申请专利；(b)为一种无法治愈的疾病制定治疗战略；(c)与日益增长的澳大利亚生物技术产业建立联系（除了与国际制药公司的现有联系之外）。