Regulation of mRNA translation by the microtubule-associated protein Tau

微管相关蛋白 Tau 对 mRNA 翻译的调节

• 批准号: DP190102789
• 负责人: Prof Jürgen Götz
• 金额: $ 32.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2022-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102789
• 关键词: Regulation; mRNA; translation; microtubule; associated

This project aims to understand the molecular processes in a cell type and subcellular compartment that underlies learning and memory formation. Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. The kinase Fyn (which is localised to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.

该项目旨在了解细胞类型和亚细胞区室中作为学习和记忆形成基础的分子过程。突触强化和记忆形成等基本神经元功能依赖于严格调控的蛋白质翻译过程。激酶 Fyn（位于形成记忆的树突棘）激活 ERK/S6 通路，导致支架蛋白 Tau 的大量翻译。更重要的是，该级联的激活依赖于 Tau。该项目旨在确定 Tau 如何激活该通路，并破译 Tau/Fyn/Tau 反馈回路的生理作用。这将有助于我们了解学习和记忆的分子调节。