Regulation of mRNA translation by the microtubule-associated protein Tau

该项目旨在了解一种细胞类型和亚细胞区室的分子过程，这是学习和记忆形成的基础。基本的神经元功能，如突触强化和记忆形成，都依赖于严格调控的蛋白质翻译过程。Fyn激酶（定位于记忆形成的树突棘）激活ERK/S6通路，导致支架蛋白Tau的大量翻译。更重要的是，这种级联的激活依赖于tau蛋白。该项目旨在确定Tau如何激活这一途径，并破译Tau/Fyn/Tau反馈回路的生理作用。这将有助于我们理解学习和记忆的分子调控。

This project aims to understand the molecular processes in a cell type and subcellular compartment that underlies learning and memory formation. Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. The kinase Fyn (which is localised to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.