Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions

研究蛋白质-蛋白质相互作用的新质谱方法

• 批准号: DP1093143
• 负责人: Prof Tara Pukala
• 金额: $ 25.08万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093143
• 关键词: Novel; Mass; Spectrometric; Approaches; Study

Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.

蛋白质蛋白质相互作用介导了所有基本细胞过程，但是蛋白质组件的结构复杂性意味着它们通常很难使用传统的分析方法来表征它们。 该项目将开发并展示新的质谱方法，以对生物蛋白络合物的结构和相互作用的分子水平描述，这又可能是药物的合理设计，用于治疗一系列人类健康状况。 该项目还将为年轻研究人员提供质谱和蛋白质科学领域最高国际标准的培训，以对澳大利亚的工业和研究受益。