Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions

研究蛋白质-蛋白质相互作用的新质谱方法

• 批准号: DP1093143
• 负责人: Prof Tara Pukala
• 金额: $ 25.08万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093143
• 关键词: Novel; Mass; Spectrometric; Approaches; Study

Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.

蛋白质之间的相互作用介导了所有基本的细胞过程，然而蛋白质组装的结构复杂性意味着它们通常很难用传统的分析方法来表征。该项目将开发和展示新的质谱方法，以在分子水平上描述生物蛋白复合物的结构和相互作用，这反过来可能为合理设计治疗一系列人类健康状况的药物奠定基础。该项目还将在质谱和蛋白质科学方面为年轻研究人员提供最高国际标准的培训，以造福澳大利亚的工业和研究。