Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions

研究蛋白质-蛋白质相互作用的新质谱方法

• 批准号: DP1093143
• 负责人: Prof Tara Pukala
• 金额: $ 25.08万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093143
• 关键词: Novel; Mass; Spectrometric; Approaches; Study

Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.

蛋白质-蛋白质相互作用介导所有基本的细胞过程，但蛋白质组装体的结构复杂性意味着它们通常难以使用传统的分析方法进行分析。 该项目将开发和展示新的质谱方法，以分子水平描述生物蛋白质复合物的结构和相互作用，这反过来又可能支持用于治疗一系列人类健康状况的药物的合理设计。 该项目还将为青年研究人员提供质谱和蛋白质科学最高国际标准的培训，以造福澳大利亚的工业和研究。