Mechanisms of longevity in C. elegans mutants with defective mitochondria.
Mechanisms of longevity in C. elegans mutants with defective mitochondria.
批准号:
223894
负责人:
Hekimi Siegfried
金额:
$34.98万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-03-01 至 2016-03-01
中文摘要
据观察,衰老是许多疾病的主要危险因素,它系统地伴随着活性氧(也称为自由基)的产生增加,这是一种高浓度有毒的分子。它
英文摘要
It has been observed that aging, which is the main risk factor for many diseases, is systematically accompanied by increased production of reactive oxygen species (also called free radicals), which are molecules that can be toxic at high concentration. It
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会议论文
Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
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批准号:379736
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项目类别:Operating Grants
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资助金额:$50.16万
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财政年份:2018
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负责人:Hekimi Siegfried
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依托单位:
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
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批准号:368962
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项目类别:Operating Grants
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资助金额:$222.05万
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财政年份:2017
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负责人:Hekimi Siegfried
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依托单位:
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
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批准号:320289
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项目类别:Operating Grants
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资助金额:$47.53万
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财政年份:2015
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负责人:Hekimi Siegfried
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依托单位:
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
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批准号:304014
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项目类别:Operating Grants
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资助金额:$45.33万
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财政年份:2014
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负责人:Hekimi Siegfried
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依托单位:
Structure, biosynthesis, and function of bile acids in C. elegans
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批准号:252035
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项目类别:Operating Grants
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资助金额:$42.16万
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财政年份:2012
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负责人:Hekimi Siegfried
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依托单位:
C. elegans models of mitochondrial deficiency in the nervous system
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批准号:235523
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项目类别:Operating Grants
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资助金额:$8.74万
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财政年份:2011
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负责人:Hekimi Siegfried
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依托单位:
Molecular and physiological mechanisms of longevity in Mclk1+/- mutants
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批准号:179427
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项目类别:Operating Grants
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资助金额:$45.42万
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财政年份:2009
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负责人:Hekimi Siegfried
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依托单位:
海外基金