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Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.

Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
受控泛醌生物合成：利用泛醌生物合成酶的诱导型小鼠突变体研究泛醌的功能和线粒体电子传递受损的生物学。
批准号：
304014
负责人：
Hekimi Siegfried
金额：
$45.33万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-03-01 至 2019-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=304014&lang=en
关键词：
Aging And Lifespan Inducible Mouse Mutants Mitochondrial Electron Transport Reactive Oxygen Species Ubiquinone Biosynthesis Ubiquinone Deficiency

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英文摘要
We are studying the multiple functions of co-enzyme Q (CoQ; CoQ10) in health and disease, and how these functions relate to the aging process. Co-enzyme Q, which is also known as "ubiquinone", has many important functions in the cell, in particular in the
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Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
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Structure, biosynthesis, and function of bile acids in C. elegans
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