Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.

受控泛醌生物合成：利用泛醌生物合成酶的诱导型小鼠突变体研究泛醌的功能和线粒体电子传递受损的生物学。

• 批准号: 304014
• 负责人: Hekimi Siegfried
• 金额: $ 45.33万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2019-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=304014&lang=en
• 关键词: Aging And Lifespan; Inducible Mouse Mutants; Mitochondrial Electron Transport; Reactive Oxygen Species; Ubiquinone Biosynthesis; Ubiquinone Deficiency

We are studying the multiple functions of co-enzyme Q (CoQ; CoQ10) in health and disease, and how these functions relate to the aging process. Co-enzyme Q, which is also known as "ubiquinone", has many important functions in the cell, in particular in the

我们正在研究辅酶Q(CoQ；CoQ10)在健康和疾病中的多种功能，以及这些功能与衰老过程的关系。辅酶Q，也被称为“泛醌”，在细胞中有许多重要的功能，特别是在