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Structure, biosynthesis, and function of bile acids in C. elegans

Structure, biosynthesis, and function of bile acids in C. elegans
线虫胆汁酸的结构、生物合成和功能
批准号:
252035
负责人:
Hekimi Siegfried
金额:
$42.16万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-03-01 至 2017-03-01

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中文摘要
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英文摘要
In the present grant application I propose to use an animal model to understand why some of the risk factors that lead to cardiovascular diseases develop preferentially in aged individuals. These risk factors, which often occur together, are obesity, diab
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Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
  • 批准号:
    379736
  • 项目类别:
    Operating Grants
  • 资助金额:
    $50.16万
  • 财政年份:
    2018
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
  • 批准号:
    368962
  • 项目类别:
    Operating Grants
  • 资助金额:
    $222.05万
  • 财政年份:
    2017
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
  • 批准号:
    320289
  • 项目类别:
    Operating Grants
  • 资助金额:
    $47.53万
  • 财政年份:
    2015
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
  • 批准号:
    304014
  • 项目类别:
    Operating Grants
  • 资助金额:
    $45.33万
  • 财政年份:
    2014
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
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