Molecular mechanisms of pro-longevity mitochondrial ROS signaling
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
批准号:
320289
负责人:
Hekimi Siegfried
金额:
$47.53万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-03-01 至 2020-03-01
中文摘要
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英文摘要
The proposed study seeks to understand the role of reactive oxygen species (ROS) in the aging process. ROS are also often called 'free radicals' and are important regulators of the function of cells, but they are also potentially toxic. In the past, peopl
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Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
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批准号:379736
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项目类别:Operating Grants
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资助金额:$50.16万
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财政年份:2018
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负责人:Hekimi Siegfried
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依托单位:
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
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批准号:368962
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项目类别:Operating Grants
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资助金额:$222.05万
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财政年份:2017
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负责人:Hekimi Siegfried
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依托单位:
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
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批准号:304014
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项目类别:Operating Grants
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资助金额:$45.33万
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财政年份:2014
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负责人:Hekimi Siegfried
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依托单位:
Structure, biosynthesis, and function of bile acids in C. elegans
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批准号:252035
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项目类别:Operating Grants
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资助金额:$42.16万
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财政年份:2012
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负责人:Hekimi Siegfried
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依托单位:
C. elegans models of mitochondrial deficiency in the nervous system
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批准号:235523
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项目类别:Operating Grants
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资助金额:$8.74万
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财政年份:2011
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负责人:Hekimi Siegfried
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依托单位:
Mechanisms of longevity in C. elegans mutants with defective mitochondria.
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批准号:223894
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项目类别:Operating Grants
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资助金额:$34.98万
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财政年份:2011
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负责人:Hekimi Siegfried
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依托单位:
Molecular and physiological mechanisms of longevity in Mclk1+/- mutants
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批准号:179427
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项目类别:Operating Grants
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资助金额:$45.42万
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财政年份:2009
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负责人:Hekimi Siegfried
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依托单位:
海外基金