ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
衰老过程和年龄依赖性疾病中的活性氧代谢和线粒体功能。
批准号：
368962
负责人：
Hekimi Siegfried
金额：
$222.05万
依托单位：
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2024-09-01
中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Most diseases that threaten Canadians, including cancer, heart disease, metabolic diseases, and neurodegenerative disease (such as Alzheimer's disease and Parkinson's disease) are associated with age: they are much more likely in older individuals. Our g
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
-
批准号：379736
-
项目类别：Operating Grants
-
资助金额：$50.16万
-
财政年份：2018
-
负责人：Hekimi Siegfried
-
依托单位：
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
-
批准号：320289
-
项目类别：Operating Grants
-
资助金额：$47.53万
-
财政年份：2015
-
负责人：Hekimi Siegfried
-
依托单位：
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
-
批准号：304014
-
项目类别：Operating Grants
-
资助金额：$45.33万
-
财政年份：2014
-
负责人：Hekimi Siegfried
-
依托单位：
Structure, biosynthesis, and function of bile acids in C. elegans
-
批准号：252035
-
项目类别：Operating Grants
-
资助金额：$42.16万
-
财政年份：2012
-
负责人：Hekimi Siegfried
-
依托单位：
C. elegans models of mitochondrial deficiency in the nervous system
-
批准号：235523
-
项目类别：Operating Grants
-
资助金额：$8.74万
-
财政年份：2011
-
负责人：Hekimi Siegfried
-
依托单位：
Mechanisms of longevity in C. elegans mutants with defective mitochondria.
-
批准号：223894
-
项目类别：Operating Grants
-
资助金额：$34.98万
-
财政年份：2011
-
负责人：Hekimi Siegfried
-
依托单位：
Molecular and physiological mechanisms of longevity in Mclk1+/- mutants
-
批准号：179427
-
项目类别：Operating Grants
-
资助金额：$45.42万
-
财政年份：2009
-
负责人：Hekimi Siegfried
-
依托单位：