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Molecular and physiological mechanisms of longevity in Mclk1+/- mutants

Molecular and physiological mechanisms of longevity in Mclk1+/- mutants
Mclk1/-突变体长寿的分子和生理机制
批准号:
179427
负责人:
Hekimi Siegfried
金额:
$45.42万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-03-01 至 2014-03-01

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中文摘要
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英文摘要
We are studying a strain of mouse mutants (Mclk1+/-) that live longer than normal mice. We have found that when we compare aged mutants to normal mice of the same age, the mutants appear physiologically younger, that is, they are healthier and more youthf
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Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
  • 批准号:
    379736
  • 项目类别:
    Operating Grants
  • 资助金额:
    $50.16万
  • 财政年份:
    2018
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
  • 批准号:
    368962
  • 项目类别:
    Operating Grants
  • 资助金额:
    $222.05万
  • 财政年份:
    2017
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
Molecular mechanisms of pro-longevity mitochondrial ROS signaling
  • 批准号:
    320289
  • 项目类别:
    Operating Grants
  • 资助金额:
    $47.53万
  • 财政年份:
    2015
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
Controlled ubiquinone biosynthesis: Investigating the functions of ubiquinone and the biology of impaired mitochondrial electron transport with inducible mouse mutants of ubiquinone biosynthetic enzymes.
  • 批准号:
    304014
  • 项目类别:
    Operating Grants
  • 资助金额:
    $45.33万
  • 财政年份:
    2014
  • 负责人:
    Hekimi Siegfried
  • 依托单位:
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