Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs

金属基抗糖尿病药物的设计与机理研究

• 批准号: DP1095310
• 负责人: Prof Peter Lay
• 金额: $ 31.35万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-14 至 2013-12-04
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1095310
• 关键词: Design; Mechanistic; Studies; Metal; Based

Metal supplements, such as chromium and vanadium, are consumed widely for their purported fat reduction and anti-diabetic activities. However, much is still to be learnt about the efficacy and safety of such metal ions and whether they have an essential role in the prevention of diabetes or, in some instances, are a risk factor for cancer. The research will provide a fundamental understanding of how these metal complexes exert their anti-diabetic effects and how they can be made safer and/or more efficacious for the treatment of type 2 diabetes, which is a rapidly expanding epidemic in developed countries.

金属补充剂，如铬和钒，因其据称的减脂和抗糖尿病活性而被广泛消费。然而，关于这些金属离子的有效性和安全性，以及它们是否在预防糖尿病方面发挥重要作用，或者在某些情况下是癌症的风险因素，还有很多东西有待了解。该研究将提供对这些金属络合物如何发挥其抗糖尿病作用的基本理解，以及如何使它们更安全和/或更有效地治疗2型糖尿病，这是发达国家迅速蔓延的流行病。