Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research

生物医学研究中的纳米探针和微探针结构和光谱研究

• 批准号: DP0664706
• 负责人: Prof Peter Lay
• 金额: $ 23.68万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-02-02 至 2008-11-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664706
• 关键词: Nanoprobe; Microprobe; Structural; Spectroscopic; Studies

Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables multi-layered information on changes in cells that occur as a function of drug treatments and disease processes. This will provide unprecedented information as to where drugs go and how they are transformed inside cells that, in turn, may revolutionalise the way in which new drugs are designed that have higher specificity and lower side effects.

突破性的微探针和纳米探针技术，包括 X 射线、可见光和红外光，可以聚焦到哺乳动物细胞的不同成分，以探究其中发生的生物化学。 每种不同波长的光都提供互补的生化信息，从而能够获得有关药物治疗和疾病过程中发生的细胞变化的多层信息。 这将提供关于药物去往何处以及它们如何在细胞内转化的前所未有的信息，进而可能彻底改变具有更高特异性和更低副作用的新药物的设计方式。