Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs

金属配合物在碳水化合物代谢中的作用 — 抗糖尿病药物

• 批准号: DP160104172
• 负责人: Prof Peter Lay
• 金额: $ 34.92万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104172
• 关键词: Roles; Metal; Complexes; Carbohydrate; Metabolism

This project aims to study the biological chemistry of chromium, vanadium, molybdenum and tungsten in glucose/fructose metabolism. Metal supplements are consumed widely for purported fat reduction and anti-diabetic activities but pose many questions about their efficacy, safety and essentiality. The project plans to explore evidence for an essential role for vanadium and molybdenum in carbohydrate metabolism and to investigate the transport, uptake and biological activities of the above metals. These fundamental chemical and biochemical studies could provide the basis of future research into improved prevention and treatment methods to reduce the incidence of type 2 diabetes.

本项目旨在研究铬、钒、钼和钨在葡萄糖/果糖代谢中的生物化学作用。金属补充剂被广泛食用，据称具有减脂和抗糖尿病的作用，但对其有效性、安全性和必要性提出了许多问题。该项目计划探索钒和钼在碳水化合物代谢中的重要作用的证据，并研究上述金属的运输、吸收和生物活性。这些基础的化学和生化研究可以为未来研究改善预防和治疗方法以降低2型糖尿病的发病率提供基础。