Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment

细胞内疾病过程及其治疗的微探针和纳米探针研究

• 批准号: DP0984722
• 负责人: Prof Peter Lay
• 金额: $ 70.59万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-28 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984722
• 关键词: Microprobe; Nanoprobe; Studies; Intracellular; Disease

Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables a deeper understanding of changes in cells that occur as a function of drug treatments and disease processes. This will provide unprecedented information as to where drugs go and how they are transformed inside cells that, in turn, may revolutionalise the way in which new drugs are designed that have higher specificity and fewer side effects.

突破性的微探针和纳米探针技术，包括X射线，可见光和红外光，可以聚焦到哺乳动物细胞的不同组成部分，以询问其中发生的生物化学。每种不同波长的光都提供了互补的生化信息，使人们能够更深入地了解细胞中作为药物治疗和疾病过程的函数而发生的变化。这将为药物的去向以及它们如何在细胞内转化提供前所未有的信息，反过来，这可能会彻底改变设计具有更高特异性和更少副作用的新药的方式。