课题基金 / 基金详情

Bioinorganic chemistry between immune cell and pathogen

Bioinorganic chemistry between immune cell and pathogen
免疫细胞与病原体之间的生物无机化学
批准号:
DP180102741
负责人:
Prof Peter Lay
金额:
$37.48万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-02-27

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中文摘要
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英文摘要
This project aims to investigate the bioinorganic chemistry that occurs when immune system cells encounter pathogens and they try to kill one another, or in the case of a pathogen, to also modify the genetics of the mammalian cell to enable its intracellular survival. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes and it was recently discovered that Cr is likely to be an important virulence factor. Similarly, Hyperaccummulation of Nickel (Ni) is also involved in virulence. The project will investigate the roles of Cr and Ni in virulence using advanced spectroscopic imaging and biochemical techniques. These insights will provide new knowledge on the innate immune system and may lead to more efficacious treatments for serious infections.
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Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
  • 批准号:
    DP210101632
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $42.2万
  • 财政年份:
    2021
  • 负责人:
    Prof Peter Lay
  • 依托单位:
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies
  • 批准号:
    LE200100043
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $25.94万
  • 财政年份:
    2020
  • 负责人:
    Prof Peter Lay
  • 依托单位:
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs
  • 批准号:
    DP160104172
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $34.92万
  • 财政年份:
    2016
  • 负责人:
    Prof Peter Lay
  • 依托单位:
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies
  • 批准号:
    DP140100176
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $36.31万
  • 财政年份:
    2014
  • 负责人:
    Prof Peter Lay
  • 依托单位:
国内基金
海外基金
SCIENCE CHINA Chemistry
接枝IKVAV多肽和NGF的水凝胶对神经干细胞分化影响及其机制的研究
  • 批准号:
    51103112
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    25.0万元
  • 批准年份:
    2011
  • 负责人:
    张平
  • 依托单位:
新型二茂铁基四咪唑类大环配体的合成、表征及其金属配合物在非均相C-C偶联反应中的应用研究
  • 批准号:
    21102132
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    25.0万元
  • 批准年份:
    2011
  • 负责人:
    张金莉
  • 依托单位:
Science China Chemistry