Bioinorganic chemistry between immune cell and pathogen
Bioinorganic chemistry between immune cell and pathogen
批准号:
DP180102741
负责人:
Prof Peter Lay
金额:
$37.48万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-02-27
中文摘要
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英文摘要
This project aims to investigate the bioinorganic chemistry that occurs when immune system cells encounter pathogens and they try to kill one another, or in the case of a pathogen, to also modify the genetics of the mammalian cell to enable its intracellular survival. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes and it was recently discovered that Cr is likely to be an important virulence factor. Similarly, Hyperaccummulation of Nickel (Ni) is also involved in virulence. The project will investigate the roles of Cr and Ni in virulence using advanced spectroscopic imaging and biochemical techniques. These insights will provide new knowledge on the innate immune system and may lead to more efficacious treatments for serious infections.
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会议论文
Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
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批准号:DP210101632
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项目类别:Discovery Projects
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资助金额:$42.2万
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财政年份:2021
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负责人:Prof Peter Lay
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依托单位:
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies
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批准号:LE200100043
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$25.94万
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财政年份:2020
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负责人:Prof Peter Lay
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依托单位:
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs
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批准号:DP160104172
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项目类别:Discovery Projects
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资助金额:$34.92万
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财政年份:2016
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负责人:Prof Peter Lay
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依托单位:
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies
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批准号:DP140100176
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项目类别:Discovery Projects
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资助金额:$36.31万
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财政年份:2014
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负责人:Prof Peter Lay
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依托单位:
The roles of metal complexes and related metalloproteins in the essential and therapeutic control of diabetes
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批准号:DP130103566
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项目类别:Discovery Projects
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资助金额:$31.98万
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财政年份:2013
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负责人:Prof Peter Lay
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依托单位:
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons
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批准号:LE110100174
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$53.34万
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财政年份:2011
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负责人:Prof Peter Lay
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依托单位:
Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs
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批准号:DP1095310
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项目类别:Discovery Projects
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资助金额:$31.35万
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财政年份:2010
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负责人:Prof Peter Lay
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依托单位:
Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment
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批准号:DP0984722
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项目类别:Discovery Projects
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资助金额:$70.59万
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财政年份:2009
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负责人:Prof Peter Lay
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依托单位:
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research
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批准号:LE0883036
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$26.67万
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财政年份:2008
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负责人:Prof Peter Lay
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依托单位:
Biomolecular chemical survival strategies of terrestrial extremophiles and the spectroscopic search for life on Mars
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批准号:LX0776464
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项目类别:Linkage - International
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资助金额:$2.68万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
The roles of metal ions in glucose metabolism and the treatment of diabetes
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批准号:DP0774173
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项目类别:Discovery Projects
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资助金额:$27.35万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research
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批准号:DP0664706
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项目类别:Discovery Projects
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资助金额:$23.68万
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财政年份:2006
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负责人:Prof Peter Lay
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依托单位:
Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials
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批准号:LE0560680
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$60.14万
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财政年份:2005
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负责人:Prof Peter Lay
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依托单位:
Metals in Medicine
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批准号:SR0354474
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项目类别:Special Research Initiatives
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资助金额:$2.0万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects
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批准号:LP0453765
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项目类别:Linkage Projects
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资助金额:$24.47万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design, Probing Mechanisms of Diseases, and Bioinorganic Chemistry
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批准号:DP0346162
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项目类别:Discovery Projects
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资助金额:$19.24万
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财政年份:2003
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负责人:Prof Peter Lay
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依托单位:
Fluorescence Detector for the Australian National Beamline Facility
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批准号:LE0346515
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$33.81万
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财政年份:2003
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负责人:Prof Peter Lay
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依托单位:
The Chemistry and Biochemistry of Chromium: Cancer and Nutrition
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批准号:DP0208409
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项目类别:Discovery Projects
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资助金额:$70.17万
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财政年份:2002
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负责人:Prof Peter Lay
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依托单位:
国内基金
海外基金
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批准号:90813026
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合成新的树枝状共轭大分子
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