课题基金 / 基金详情

Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects

Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects
高效、低副作用的金属类抗炎药
批准号:
LP0453765
负责人:
Prof Peter Lay
金额:
$24.47万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-06-10 至 2008-05-23

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中文摘要
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英文摘要
Non-steroidal anti-inflammatory drugs (NSAIDs) have widespread human and veterinary applications for the treatment of arthritis and other inflammatory diseases, but their utility is limited by often severe gastrointestinal, renal and cardiac side-effects. The recently heralded COX-2 inhibitors have not lived up to their expectations in terms of efficacy and side-effects, therefore, there is a need to develop new potent, but safer, NSAIDs. This project is aimed at using the results from new lead compounds to design NSAIDs with much greater efficacy and much less side effects than those currently available.
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Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
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