The development of copper-free click chemistry to label biomolecules within living cells

开发无铜点击化学来标记活细胞内的生物分子

• 批准号: DP1095425
• 负责人: Prof Sally-Ann Poulsen
• 金额: $ 23.66万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1095425
• 关键词: development; copper; free; click; chemistry

Understanding how cells work is central to modern advances in biomedical science, however many cellular processes are invisible to the researcher because of a lack of appropriate tools. This proposal will apply modern chemistry approaches to the design of new chemical tools for visualising biomolecules within living cells and for investigating cell function. This project brings together experts in chemistry, stem cells and malaria and has applications for development of much needed new therapeutics. This research will advance biomedical research and generate new discoveries for a competitive advantage for Australian science, with potential economic return for the nation.

了解细胞如何工作是现代生物医学科学进步的核心，然而，由于缺乏适当的工具，许多细胞过程对研究人员来说是不可见的。该提案将应用现代化学方法来设计新的化学工具，用于可视化活细胞内的生物分子和研究细胞功能。该项目汇集了化学、干细胞和疟疾方面的专家，并应用于开发急需的新疗法。这项研究将促进生物医学研究，并为澳大利亚科学的竞争优势产生新的发现，为国家带来潜在的经济回报。