Chemical probes for visualising DNA synthesis

用于可视化 DNA 合成的化学探针

• 批准号: DP180102601
• 负责人: Prof Sally-Ann Poulsen
• 金额: $ 29.79万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-04 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102601
• 关键词: Chemical; probes; visualising; DNA; synthesis

This project aims to develop chemical probes to quantify DNA synthesis in complex mammalian and parasite cellular systems in conjunction with image-based technologies. Chemical probes are small molecule reagents that have a profound impact on our ability to answer fundamental questions about biological processes within living cells. The probes will be differentiated from current probes that are toxic or incompatible with state-of-the art imaging. The project expects to generate intellectual property with potential for development into commercial products that allow researchers expanded opportunities to study complex biological processes.

该项目旨在开发化学探针，以结合基于图像的技术来量化复杂哺乳动物和寄生虫细胞系统中的DNA合成。化学探针是小分子试剂，对我们回答有关活细胞内生物过程的基本问题的能力产生深远影响。这些探针将区别于有毒或与最新成像技术不兼容的当前探针。该项目预计将产生具有开发商业产品潜力的知识产权，使研究人员有更多的机会研究复杂的生物过程。