Inhibition of membrane-bound carbonic anhydrases with small molecules as a novel approach to target a safe and effective treatment for solid tumours.

用小分子抑制膜结合碳酸酐酶作为一种安全有效治疗实体瘤的新方法。

• 批准号: DP110100071
• 负责人: Prof Sally-Ann Poulsen
• 金额: $ 26.74万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110100071
• 关键词: Inhibition; membrane; bound; carbonic; anhydrases

Over 85 per cent of human cancers are solid tumours and the prognosis for patients with advanced solid tumours is extremely poor owing to resistance to conventional chemo- and radio- therapies. Our research will underpin the development of new, safe and effective drug treatment options for cancer patients with solid tumours.

85%以上的人类癌症是实体瘤，晚期实体瘤患者的预后极差，原因是对常规化疗和放疗有抗药性。我们的研究将为实体瘤癌症患者开发新的，安全有效的药物治疗选择奠定基础。