Chemical probes to dissect the cell cycle of globally important parasites

化学探针剖析全球重要寄生虫的细胞周期

• 批准号: DP220102618
• 负责人: Prof Sally-Ann Poulsen
• 金额: $ 29.9万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-27 至 2025-05-26
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102618
• 关键词: Chemical; probes; dissect; cell; cycle

This project aims to develop new reagents, called chemical probes, to visualise key biological events in globally important pathogens. We will use innovative chemistry to modify the building blocks of DNA and provide researchers with essential tools to 'see' DNA synthesis in order to study growth and replication of pathogens in combination with microscopy. This project expects to support a major technical advance that will address important gaps in our understanding of many pathogens (e.g. those that cause malaria and tuberculosis), at both the cellular and molecular levels. This should provide significant benefits by enabling researchers worldwide to identify new intervention opportunities that target unique aspects of pathogen biology.

该项目旨在开发称为化学探针的新试剂，以可视化全球重要病原体中的关键生物事件。我们将使用创新的化学来修改DNA的构建模块，并为研究人员提供必要的工具来“看到”DNA合成，以便结合显微镜来研究病原体的生长和复制。该项目预计将支持一项重大技术进步，以解决我们在细胞和分子水平上对许多病原体（例如导致疟疾和结核病的病原体）理解的重要差距。这将使世界各地的研究人员能够确定针对病原体生物学独特方面的新干预机会，从而带来重大益处。