Refinement of dynamic combinatorial chemistry as a drug discovery tool

动态组合化学作为药物发现工具的改进

• 批准号: DP0343419
• 负责人: Prof Sally-Ann Poulsen
• 金额: $ 13.92万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343419
• 关键词: Refinement; dynamic; combinatorial; chemistry; drug

Medicinal chemistry is constantly being challenged to develop efficient methodologies for the synthesis of compounds for drug discovery. Following completion of the Human Genome project, the cloning and expression of new proteins will proceed at an accelerated rate. In the absence of biochemical knowledge of the target protein there is a growing interest in techniques that expand the structural and biological diversity of compound libraries. Dynamic combinatorial chemistry is an innovative technology with the capacity for supporting the shift from focussed to diverse compound libraries. This application seeks funding to refine dynamic combinatorial chemistry into an effective drug discovery tool.

药物化学不断受到挑战，以开发有效的方法来合成药物发现的化合物。人类基因组计划完成后，新蛋白质的克隆和表达将加速进行。在缺乏靶蛋白的生物化学知识的情况下，人们对扩大化合物文库的结构和生物多样性的技术越来越感兴趣。动态组合化学是一种创新技术，能够支持从集中到多样化的化合物库的转变。该申请寻求资金将动态组合化学改进为有效的药物发现工具。