Unsaturated Reactive Intermediates and Related Chemistry

有机和高分子化学的这项资助提供了 支持彼得·斯坦博士的研究，大学 犹他州。这项工作的重点是准备和理解 有机化学中不寻常的键合物种。合成用途 这些物种也将被研究。 将研究三个独立的领域：a）不饱和 卡宾，B）有机金属化学和c）应变环 系统. 使用硅作为手性助剂沿着 将研究亚烷基卡宾叶立德。 的详细 金属介导的不饱和交叉偶联的机制将是 使用Pt作为金属和乙烯基三氟甲磺酸酯作为 印刷受体. 不同金属有机化合物的相互作用 还将探测具有炔基乙烯基三氟甲磺酸酯的亲核试剂。 重点介绍了新的烷基亚甲基丙烯的化学 氧化，环加成，和金属络合物将是 沿着新的、新颖的菌株的制备， 环系统动力学，立体化学，结构反应性， 核磁共振和X射线结构测定将是主要的 使用的技术和工具。 虽然这些研究 主要是基本性质的，它们将提供 深入了解了 合成有用的反应。 他们还将提供一个 更好地理解有机金属途径， 基本的机械见解目前是有限的， 非常需要。

This grant in Organic and Macromolecular Chemistry provides support for the research of Dr. Peter Stang, University of Utah. The work is focused on preparing and understanding unusual bonding species in organic chemistry. The synthetic use of such species also will be studied. Three independent areas will be examined: a) unsaturated carbenes, b) organometallic chemistry and c) strained ring systems. The uses of silicon as a chiral auxiliary along with alkylidenecarbene-ylides will be studied. The detailed mechanism of metal-mediated unsaturated cross couplings will be examined using Pt as the metal and vinyl triflates as the substrates. The interaction of varied organometallic nucleophiles with alkynylvinyl triflates will also be probed. The chemistry of the new alkylidencycloproparenes with emphasis on oxidation, cycloadditions, and metal complexes will be developed along with the preparation of new, novel strained ring systems. Kinetics, stereochemistry, structure-reactivity, NMR, and X-ray structure determinations will be the major techniques and tools employed. Although these studies are primarily of a fundamental nature, they will provide considerable insight into the detailed mechanism of synthetically useful reactions. They will also provide a better understanding of organometallic pathways where fundamental mechanistic insights are currently limited and greatly needed.