Unsaturated Reactive Intermediates and Related Chemistry

不饱和反应中间体及相关化学

• 批准号: 8802622
• 负责人: Peter Stang
• 金额: $ 23.35万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8802622&HistoricalAwards=false
• 关键词: Unsaturated; Reactive; Intermediates; Related; Chemistry

This grant in Organic and Macromolecular Chemistry provides support for the research of Dr. Peter Stang, University of Utah. The work is focused on preparing and understanding unusual bonding species in organic chemistry. The synthetic use of such species also will be studied. Three independent areas will be examined: a) unsaturated carbenes, b) organometallic chemistry and c) strained ring systems. The uses of silicon as a chiral auxiliary along with alkylidenecarbene-ylides will be studied. The detailed mechanism of metal-mediated unsaturated cross couplings will be examined using Pt as the metal and vinyl triflates as the substrates. The interaction of varied organometallic nucleophiles with alkynylvinyl triflates will also be probed. The chemistry of the new alkylidencycloproparenes with emphasis on oxidation, cycloadditions, and metal complexes will be developed along with the preparation of new, novel strained ring systems. Kinetics, stereochemistry, structure-reactivity, NMR, and X-ray structure determinations will be the major techniques and tools employed. Although these studies are primarily of a fundamental nature, they will provide considerable insight into the detailed mechanism of synthetically useful reactions. They will also provide a better understanding of organometallic pathways where fundamental mechanistic insights are currently limited and greatly needed.

这项在有机和大​​分子化学方面的赠款为犹他大学彼得·斯坦博士的研究提供了支持。这项工作的重点是准备和理解有机化学中异常粘结物种。还将研究此类物种的合成使用。 将检查三个独立的区域：a）不饱和卡宾，b）有机金属化学和c）紧张的环系统。 将研究硅作为手性辅助的用途以及烷基二烯烯基烯基体。 金属介导的不饱和交叉耦合的详细机制将以PT作为金属和乙烯基三叶材料作为底物进行检查。 还将探测各种有机金属亲核试剂与烷基尼林三角纤维的相互作用。 新型烷基丙烷丙酚烯的化学性质，重点是氧化，环加成和金属络合物，并随着新型新型应变环系统的制备而开发。动力学，立体化学，结构反应性，NMR和X射线结构确定将是使用的主要技术和工具。 尽管这些研究主要具有基本性质，但它们将对合成有用反应的详细机制提供大量见解。 他们还将更好地理解有限的机械洞察力目前受到限制和非常需要的基本机理见解。