Unsaturated Reactive Intermediates and Related Chemistry

不饱和反应中间体及相关化学

• 批准号: 8802622
• 负责人: Peter Stang
• 金额: $ 23.35万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8802622&HistoricalAwards=false
• 关键词: Unsaturated; Reactive; Intermediates; Related; Chemistry

This grant in Organic and Macromolecular Chemistry provides support for the research of Dr. Peter Stang, University of Utah. The work is focused on preparing and understanding unusual bonding species in organic chemistry. The synthetic use of such species also will be studied. Three independent areas will be examined: a) unsaturated carbenes, b) organometallic chemistry and c) strained ring systems. The uses of silicon as a chiral auxiliary along with alkylidenecarbene-ylides will be studied. The detailed mechanism of metal-mediated unsaturated cross couplings will be examined using Pt as the metal and vinyl triflates as the substrates. The interaction of varied organometallic nucleophiles with alkynylvinyl triflates will also be probed. The chemistry of the new alkylidencycloproparenes with emphasis on oxidation, cycloadditions, and metal complexes will be developed along with the preparation of new, novel strained ring systems. Kinetics, stereochemistry, structure-reactivity, NMR, and X-ray structure determinations will be the major techniques and tools employed. Although these studies are primarily of a fundamental nature, they will provide considerable insight into the detailed mechanism of synthetically useful reactions. They will also provide a better understanding of organometallic pathways where fundamental mechanistic insights are currently limited and greatly needed.

这项有机和大分子化学基金为犹他大学Peter Stang博士的研究提供了支持。本工作的重点是制备和理解有机化学中不寻常的键合物质。还将研究这些物种的合成用途。将研究三个独立的领域：a)不饱和碳，b)有机金属化学和c)应变环系统。本文将研究硅作为手性助剂与烷基烯基碳酰化物的应用。以铂为金属，三氟乙烯为底物，研究了金属介导的不饱和交叉耦合的详细机理。各种有机金属亲核试剂与三氟乙烯基乙烯酯的相互作用也将被探讨。随着新的应变环体系的制备，新的烷基环丙烷的化学研究将以氧化、环加成和金属配合物为重点。动力学、立体化学、结构反应性、核磁共振和x射线结构测定将是主要的技术和工具。虽然这些研究主要是基础性质的，但它们将为合成有用反应的详细机制提供相当大的见解。它们还将提供对有机金属途径的更好理解，在这些途径中，基本的机制见解目前是有限的，而且非常需要。