Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
验证人法呢基焦磷酸合酶 (hFPPS) 作为治疗靶点,并设计用于治疗多发性骨髓瘤和神经退行性疾病的临床前候选药物。
基本信息
- 批准号:265657
- 负责人:
- 金额:$ 51.28万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-09-01 至 2017-09-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The enzyme farnesyl pyrophosphate synthase (hFPPS) is responsible for the biosynthesis of farnesyl pyrophosphate (FPP), a key metabolite in the biochemistry and physiology of the human body. Abnormally high activity of hFPPS has been implicated in numero
法尼基焦磷酸合成酶(hFPPS)负责法尼基焦磷酸(FPP)的生物合成,FPP是人体生物化学和生理学的关键代谢物。异常高活性的hFPPS已牵连在许多
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tsantrizos Youla S其他文献
Tsantrizos Youla S的其他文献
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{{ truncateString('Tsantrizos Youla S', 18)}}的其他基金
Molecular Tools that Block Maturation of the Nuclear Lamin A, Leading to Decrease in Proliferation and Metastasis of Pancreatic Ductal Adenocarcinoma and Colorectal Cancer
阻止核纤层蛋白 A 成熟的分子工具,可减少胰腺导管腺癌和结直肠癌的增殖和转移
- 批准号:
461368 - 财政年份:2022
- 资助金额:
$ 51.28万 - 项目类别:
Operating Grants
Validation of the human geranylgeranyl pyrophosphate synthase (hGGPPS) as a therapeutic target for cancer chemotherapy and design of pre-clinical candidates for the treatment of multiple myeloma
验证人香叶基香叶基焦磷酸合酶 (hGGPPS) 作为癌症化疗的治疗靶点,并设计治疗多发性骨髓瘤的临床前候选药物
- 批准号:
380326 - 财政年份:2018
- 资助金额:
$ 51.28万 - 项目类别:
Operating Grants
Benchmark proprietary pyridine- and thienopyrimidine-based bisphosphonates against the standard of care drug Zometa® in the treatment of multiple myeloma
将基于吡啶和噻吩并嘧啶的专利双膦酸盐与治疗多发性骨髓瘤的护理药物 Zometa® 标准进行基准比较
- 批准号:
293953 - 财政年份:2013
- 资助金额:
$ 51.28万 - 项目类别:
Operating Grants
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