Validation of the human geranylgeranyl pyrophosphate synthase (hGGPPS) as a therapeutic target for cancer chemotherapy and design of pre-clinical candidates for the treatment of multiple myeloma
验证人香叶基香叶基焦磷酸合酶 (hGGPPS) 作为癌症化疗的治疗靶点,并设计治疗多发性骨髓瘤的临床前候选药物
基本信息
- 批准号:380326
- 负责人:
- 金额:$ 64.34万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-03-01 至 2023-03-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The human enzyme geranylgeranyl pyrophosphate synthase (hGGPPS) is responsible for the biosynthesis of the metabolite geranylgeranyl pyrophosphate (GGPP), which plays an important role in activating proteins involved in cancer progression. Recent biochemi
人类酵素香叶基焦磷酸合成酶(hGGPPS)负责代谢产物香叶基焦磷酸(GGPP)的生物合成,GGPP在激活参与癌症进展的蛋白质中起重要作用。最近biochemi
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Tsantrizos Youla S其他文献
Tsantrizos Youla S的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Tsantrizos Youla S', 18)}}的其他基金
Molecular Tools that Block Maturation of the Nuclear Lamin A, Leading to Decrease in Proliferation and Metastasis of Pancreatic Ductal Adenocarcinoma and Colorectal Cancer
阻止核纤层蛋白 A 成熟的分子工具,可减少胰腺导管腺癌和结直肠癌的增殖和转移
- 批准号:
461368 - 财政年份:2022
- 资助金额:
$ 64.34万 - 项目类别:
Operating Grants
Benchmark proprietary pyridine- and thienopyrimidine-based bisphosphonates against the standard of care drug Zometa® in the treatment of multiple myeloma
将基于吡啶和噻吩并嘧啶的专利双膦酸盐与治疗多发性骨髓瘤的护理药物 Zometa® 标准进行基准比较
- 批准号:
293953 - 财政年份:2013
- 资助金额:
$ 64.34万 - 项目类别:
Operating Grants
Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
验证人法呢基焦磷酸合酶 (hFPPS) 作为治疗靶点,并设计用于治疗多发性骨髓瘤和神经退行性疾病的临床前候选药物。
- 批准号:
265657 - 财政年份:2012
- 资助金额:
$ 64.34万 - 项目类别:
Operating Grants
相似海外基金
I-Corps: Translation Potential of a High Throughput Drug Discovery Platform for Protein Degraders
I-Corps:蛋白质降解剂高通量药物发现平台的转化潜力
- 批准号:
2419488 - 财政年份:2024
- 资助金额:
$ 64.34万 - 项目类别:
Standard Grant
FMO/ML-Guided Drug Design: Accelerating Novel Inhibitor Development and Drug Discovery
FMO/ML 引导的药物设计:加速新型抑制剂的开发和药物发现
- 批准号:
24K20888 - 财政年份:2024
- 资助金额:
$ 64.34万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Creating an intracellular screening platform for cyclic peptide drug discovery
创建用于环肽药物发现的细胞内筛选平台
- 批准号:
EP/Z533002/1 - 财政年份:2024
- 资助金额:
$ 64.34万 - 项目类别:
Research Grant
SBIR Phase I: High-Throughput Direct Ratiometric Calorimeter for Drug Discovery
SBIR 第一阶段:用于药物发现的高通量直接比率量热仪
- 批准号:
2402322 - 财政年份:2024
- 资助金额:
$ 64.34万 - 项目类别:
Standard Grant
Development of phage technology to precise control of intestinal microbiota disturbance for novel drug discovery
开发噬菌体技术精确控制肠道微生物群紊乱以促进新药研发
- 批准号:
23K18394 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of drug discovery platform for neurodegenerative diseases using new 3D culture method
利用新的3D培养方法开发神经退行性疾病药物发现平台
- 批准号:
22KJ2712 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters
质谱方法可解决膜转运蛋白药物发现中的能力差距
- 批准号:
2877802 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:
Studentship
Tackling the pandemic of antibiotic-resistant infections: An artificial intelligence approach to new druggable therapeutic targets and drug discovery
应对抗生素耐药性感染的流行:利用人工智能方法实现新的药物治疗靶点和药物发现
- 批准号:
MR/X009246/1 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:
Research Grant
Comprehensive development strategy of modality-specific "intellectual property" and "cultivation" with an eye on "pharmaceutical affairs" in academia drug discovery
学术界新药研发着眼“药事”的模式“知识产权”与“培育”综合发展策略
- 批准号:
23K02551 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovery-Driven Mathematics and Artificial Intelligence for Biosciences and Drug Discovery
用于生物科学和药物发现的发现驱动数学和人工智能
- 批准号:
10551576 - 财政年份:2023
- 资助金额:
$ 64.34万 - 项目类别:














{{item.name}}会员




