Validation of the human geranylgeranyl pyrophosphate synthase (hGGPPS) as a therapeutic target for cancer chemotherapy and design of pre-clinical candidates for the treatment of multiple myeloma
Validation of the human geranylgeranyl pyrophosphate synthase (hGGPPS) as a therapeutic target for cancer chemotherapy and design of pre-clinical candidates for the treatment of multiple myeloma
验证人香叶基香叶基焦磷酸合酶 (hGGPPS) 作为癌症化疗的治疗靶点，并设计治疗多发性骨髓瘤的临床前候选药物
批准号：
380326
负责人：
Tsantrizos Youla S
金额：
$64.34万
依托单位：
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-03-01 至 2023-03-01
中文摘要
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英文摘要
The human enzyme geranylgeranyl pyrophosphate synthase (hGGPPS) is responsible for the biosynthesis of the metabolite geranylgeranyl pyrophosphate (GGPP), which plays an important role in activating proteins involved in cancer progression. Recent biochemi
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负责人：Tsantrizos Youla S
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依托单位：
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财政年份：2013
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依托单位：
Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
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批准号：265657
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财政年份：2012
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负责人：Tsantrizos Youla S
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依托单位：
海外基金
