Understanding how a family of chloride pumps and channels are regulated

了解如何调节一系列氯泵和通道

• 批准号: DP150100673
• 负责人: Prof Michael Parker
• 金额: $ 51.87万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100673
• 关键词: Understanding; how; family; chloride; pumps

This project examines how a major family of chloride channels and pumps, found in nearly all organisms, works at the molecular level and how it is modulated by chemical signals from within cells. The expected outcomes are to demonstrate novel mechanisms general to these essential proteins and to provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this work aims to lead to the development of novel engineered proteins that can act as sub-microscopic electrical 'switches' and highly specific sensors for a variety of molecules for nanotechnology and biotechnology applications.

该项目研究了几乎所有生物体中发现的一个主要的氯离子通道和泵家族如何在分子水平上工作，以及如何通过细胞内的化学信号进行调节。预期的结果是展示这些必需蛋白质的新机制，并为理解所有生命王国的重要生理过程提供基本见解。最终，这项工作的目的是导致开发新的工程蛋白质，可以作为亚微观电子“开关”和高度特异性传感器的各种分子的纳米技术和生物技术应用。