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Hydrogen-deuterium exchange system - a missing link in protein analysis

Hydrogen-deuterium exchange system - a missing link in protein analysis
氢-氘交换系统——蛋白质分析中缺失的环节
批准号：
LE210100122
负责人：
Prof Michael Parker
金额：
$48.34万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Linkage Infrastructure, Equipment and Facilities
财政年份：
2021
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2021-01-01 至 2021-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/LE210100122
关键词：
Hydrogendeuteriumexchangesystemmissing

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英文摘要
Proteins are highly dynamic molecules that are essential to life. This project aims to acquire a fully automated and integrated hydrogen-deuterium exchange system, a powerful tool for analysing the motion of proteins and their interactions with other molecules. Expected outcomes include a new capability for biology labs around Australia by (1) increasing success rates of difficult projects that aim to visualise 3D protein structures and (2) providing rapid information about protein interaction sites. Anticipated benefits include the generation of dynamic data that will be highly complementary to static pictures of protein structures. This will enable clever design of new proteins with beneficial uses in the biotechnology industry.
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