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Understanding how pore-forming proteins punch holes in membranes

Understanding how pore-forming proteins punch holes in membranes
了解成孔蛋白如何在膜上打孔
批准号：
DP160101874
负责人：
Prof Michael Parker
金额：
$43.68万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2016
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2016-01-01 至 2020-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101874
关键词：
Understandinghowporeformingproteins

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英文摘要
This project aims to unravel missing molecular details of how a major superfamily of proteins is able to drill holes in cell membranes. Animals, plants, fungi and bacteria all use pore-forming proteins as cell-killing weapons of mass destruction. Despite their lethal nature and their roles in infection and immunity, how these proteins work remains enigmatic. Project outcomes could reveal novel mechanisms general to these essential proteins and provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, the knowledge gained may prove useful in the engineering of membrane pores as highly specific sensors for a variety of molecules with nanotechnology and biotechnology applications.
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