Molecular analysis of glutathione transferase interactions with drugs and physiological ligands

谷胱甘肽转移酶与药物和生理配体相互作用的分子分析

• 批准号: DP0770301
• 负责人: Prof Michael Parker
• 金额: $ 18.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770301
• 关键词: Molecular; analysis; glutathione; transferase; interactions

Proteins called glutathione transferases protect us from toxic molecules that we ingest, breathe in or are by-products of normal metabolism. The same proteins also bind to many types of drugs leading them to be excreted from the body. In this project molecular structures of glutathione transferases bound to anti-cancer drugs will be determined as the basis for devising inhibitors of the protein that will make drugs much more effective.

被称为谷胱甘肽转移酶的蛋白质保护我们免受有毒分子的伤害，这些有毒分子是我们摄入、吸入或作为正常新陈代谢的副产品。同样的蛋白质还与多种药物结合，导致它们从体内排泄出来。在这个项目中，将确定与抗癌药物结合的谷胱甘肽转移酶的分子结构，作为设计使药物更有效的蛋白质抑制剂的基础。