Molecular analysis of glutathione transferase interactions with drugs and physiological ligands
Molecular analysis of glutathione transferase interactions with drugs and physiological ligands
批准号:
DP0770301
负责人:
Prof Michael Parker
金额:
$18.25万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2009-12-31
中文摘要
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英文摘要
Proteins called glutathione transferases protect us from toxic molecules that we ingest, breathe in or are by-products of normal metabolism. The same proteins also bind to many types of drugs leading them to be excreted from the body. In this project molecular structures of glutathione transferases bound to anti-cancer drugs will be determined as the basis for devising inhibitors of the protein that will make drugs much more effective.
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