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Pore-forming toxins: more than one way to make a hole

Pore-forming toxins: more than one way to make a hole
成孔毒素:形成孔洞的方法不止一种
批准号:
DP200102871
负责人:
Prof Michael Parker
金额:
$39.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2020
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2020-01-02 至 2023-01-01

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中文摘要
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英文摘要
Animals, plants, fungi and bacteria all use pore-forming proteins as cell-killing weapons of mass destruction. Despite their lethal nature and their roles in infection and immunity, how these proteins work remains enigmatic. This project aims to unravel missing molecular details of how a major superfamily of such proteins is able to drill holes in cell membranes. The outcomes could reveal novel mechanisms general to these proteins and provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this knowledge may guide the design of artificial protein pores that are selective for specific molecules with applications such as measuring metal ions, sugars, pesticides or pollutants.
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国内基金
海外基金
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