Pore-forming toxins: more than one way to make a hole

成孔毒素：形成孔洞的方法不止一种

• 批准号: DP200102871
• 负责人: Prof Michael Parker
• 金额: $ 39.33万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-02 至 2023-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102871
• 关键词: Pore; forming; toxins; more; than

Animals, plants, fungi and bacteria all use pore-forming proteins as cell-killing weapons of mass destruction. Despite their lethal nature and their roles in infection and immunity, how these proteins work remains enigmatic. This project aims to unravel missing molecular details of how a major superfamily of such proteins is able to drill holes in cell membranes. The outcomes could reveal novel mechanisms general to these proteins and provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this knowledge may guide the design of artificial protein pores that are selective for specific molecules with applications such as measuring metal ions, sugars, pesticides or pollutants.

动物、植物、真菌和细菌都使用成孔蛋白作为大规模杀伤细胞的武器。尽管它们具有致命的性质，并且在感染和免疫中发挥作用，但这些蛋白质如何工作仍然是个谜。该项目旨在解开这些蛋白质的主要超家族如何能够在细胞膜上钻孔的分子细节。这些结果可以揭示这些蛋白质的新机制，并为理解所有生命王国的重要生理过程提供基本见解。最终，这些知识可以指导人工蛋白质孔的设计，这些孔对特定分子具有选择性，应用于测量金属离子，糖，农药或污染物等。