Study of a Serum Factor that Activates the Inositol System

激活肌醇系统的血清因子的研究

• 批准号: 9010398
• 负责人: Gabor TIGYI
• 金额: $ 18.45万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-15 至 1993-03-24
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9010398&HistoricalAwards=false
• 关键词: Study; Serum; Factor; Activates; Inositol

The discovery of a new substance, found in the blood serum of many vertebrates, including humans, has been purified and preliminary biochemical evidence indicates that the factor is a special type of albumin. The factor activates a very general intracellular messenger system which is involved in many vital processes. Studies show that this serum factor inhibits the multiplication of cancer cells and also causes the retraction of nerve cell processes. The substance is not present in normal cerebrospinal fluid, but it is present in cerebrospinal fluid of patients following neurotrauma. This factor may play a role in injury and repair of the nervous system. The main goal of this project is to determine the amino acid sequence and structure of the active site of the serum factor using enzymatic and chemical fragmentation of the factor combined with methods of protein purification and structural analysis. Blood serum and albumin are widely used in medicine and in tissue culture. Gaining more knowledge about this factor will have important implications for both basic and medical sciences.

一种新物质的发现，发现在血清中， 许多脊椎动物，包括人类，已经被纯化， 初步的生化证据表明，该因素是一个 特殊类型的白蛋白。 这个因素激活了一个非常普遍的 细胞内信使系统参与许多重要的 流程. 研究表明，这种血清因子可以抑制 增殖的癌细胞，也导致收缩， 神经细胞突起 该物质不存在于正常 脑脊液，但它存在于脑脊液中， 神经创伤后的患者 这一因素可能在以下方面发挥作用： 神经系统的损伤和修复。 这个的主要目标 项目是确定氨基酸序列和结构的 血清因子的活性部位， 因子片段化结合蛋白质方法 纯化和结构分析。 血清和白蛋白 被广泛用于医学和组织培养。 获得更多 了解这一因素将对 包括基础科学和医学。