Study of a Serum Factor that Activates the Inositol System

9321940提吉 该项目继续研究一种新的，但尚未完全确定的一类脂质介质与生长因子样性质产生的血液凝固。 这些磷脂介质显示类似于那些更微妙和复杂的生长因子蛋白质的功能。 磷脂介体的简单结构允许它们在工业规模上容易地化学合成，成本比蛋白质生长因子低数百倍。 这些天然存在的分子是响应于损伤而产生的，不仅在血液中，而且在神经系统中;实验表明，它们可能在再生和伤口愈合的启动中发挥生理作用。 目前的项目设定了两个目标：1）确定凝血过程中产生的磷脂介质的结构，2）建立导致活化细胞中生长因子样脂质介质产生的主要生化途径。 预计更多地了解这些因素最终可以设计和合成新的药物，以防止继发性神经元死亡和随后的瘫痪。 ***

9321940 Tigyi This project continues to research a novel and yet not fully identified class of lipid mediators with growth factor-like properties generated during blood clotting. These phospholipid mediators display functions similar to those of the more delicate and complicated growth factor proteins. The simple structure of the phospholipid mediators permits their easy chemical synthesis on an industrial scale, at a cost hundreds of times less than that of protein growth factors. These naturally occurring molecules are generated in response to injury, not only in the blood, but also in the nervous system; and experiments indicate that they are likely to play a physiological role in the initiation of regeneration and wound healing. The current project sets two goals: 1) determine the structure of the phospholipid mediators generated during blood clotting, and 2) establish the main biochemical pathways leading to the production of growth factor-like lipid mediators in activated cells. It is anticipated that learning more about these factors can ultimately lead to the design and synthesis of new drugs to prevent secondary neuronal death and the ensuing paralysis. ***