Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein

神经铜稳态：阿尔茨海默病淀粉样蛋白前体蛋白的作用

• 批准号: DP0985963
• 负责人: Prof Ashley Bush
• 金额: $ 22.84万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985963
• 关键词: Neural; Copper; Homeostasis; role; Alzheimer

Alzheimer's disease (AD) is creating a growing burden upon Australian medical resources. Copper plays an important role in the development of AD, and drugs designed to adjust brain copper levels are being tested for AD treatment and show therapeutic benefits. This project will determine how copper is involved in AD so that more effective drugs can be developed. Focus will primarily be on copper-binding proteins central to AD, including amyloid-beta, and their role in AD development. Upon completion of this project, we expect to better understand neural copper metabolism in health and in AD pathology, with outcomes directly applicable to therapeutic AD intervention.

阿尔茨海默病（AD）正在给澳大利亚的医疗资源造成越来越大的负担。铜在AD的发展中起着重要作用，旨在调节脑铜水平的药物正在测试AD治疗并显示出治疗益处。该项目将确定铜如何参与AD，以便开发更有效的药物。重点将主要集中在铜结合蛋白的核心AD，包括淀粉样β蛋白，以及它们在AD发展中的作用。在这个项目完成后，我们期望更好地了解健康和AD病理学中的神经铜代谢，其结果直接适用于治疗性AD干预。