Molecular study of copper-promoted ubiquitination
Molecular study of copper-promoted ubiquitination
批准号:
DP190102573
负责人:
Prof Ashley Bush
金额:
$29.49万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2021-12-31
中文摘要
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英文摘要
This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to illuminate the molecular nature of this copper action. Expected outcomes include an understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration. Potential benefits include new strategies to intervene in copper-related disorders.
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Brain metal neurochemistry: mechanism-driven drug discovery for neurodegeneration
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财政年份:2016
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批准号:nhmrc : GNT1113593
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财政年份:2016
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依托单位:
Iron accumulation in the nematode C.elegans: a model of ageing
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财政年份:2013
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依托单位:
Australia Fellowship
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财政年份:2011
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依托单位:
Biological Metals in Neurodegeneration
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批准号:nhmrc : 1002222
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项目类别:NHMRC Research Fellowships
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资助金额:$5.3万
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财政年份:2011
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依托单位:
Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein
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财政年份:2009
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依托单位:
The Role of Amyloid Protein Precursor in Mammalian Copper Transport
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批准号:DP0664068
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项目类别:Discovery Projects
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资助金额:$32.17万
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依托单位:
The Role of Metals in the Biology of the Ageing Brain
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资助金额:$107.08万
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依托单位:
Novel therapies for alzheimer's disease based on a-beta-metal interactions
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资助金额:$26.69万
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财政年份:2001
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依托单位:
Alzheimer's disease amyloid: a corrupted antioxidant?
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财政年份:1998
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负责人:Prof Ashley Bush
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依托单位:
国内基金
海外基金
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