Brain metal neurochemistry: mechanism-driven drug discovery for neurodegeneration

脑金属神经化学：机制驱动的神经退行性疾病药物发现

• 批准号: nhmrc : GNT1103703
• 负责人: Prof Ashley Bush
• 金额: $ 85.2万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/brain-metal-neurochemistry-discovery-neurodegeneration/1346297
• 关键词: Brain; metal; neurochemistry; mechanism; driven

Alzheimer’s disease (AD) is a complex disease where certain proteins congeal in the brain and metals accumulate. This project investigates the function of the proteins in microscopically transporting the metals. It will also look for tests that predict the onset of AD by measuring iron and iron related proteins by using special brain imaging (MRI), and measurements in spinal fluid. Finally, it will test drug candidates that target the metals, in animal models of AD, and in early clinical trials.

阿尔茨海默病(AD)是一种复杂的疾病，某些蛋白质在大脑中凝结，金属积累。这个项目研究了蛋白质在金属微观运输中的功能。它还将寻找通过使用特殊的脑成像(MRI)来测量铁和铁相关蛋白以及在脊髓液中进行测量来预测AD发病的测试。最后，它将在AD的动物模型和早期临床试验中测试针对这些金属的候选药物。