Biological Metals in Neurodegeneration

神经退行性疾病中的生物金属

• 批准号: nhmrc : 1002222
• 负责人: Prof Ashley Bush
• 金额: $ 5.3万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biological-metals-neurodegeneration/108787
• 关键词: Biological; Metals; Neurodegeneration

Professor Ashley Bush has extensively researched the contribution of metal biochemistry to Alzheimer�s and Parkinson�s diseases. In the current proposal he will lead the clinical testing of a new drug that combats the abnormal accumulation of metals in Alzheimer�s brain pathology, he will search for abnormal metal-interactions with blood proteins as a potential predictive test, and he will study the roles of various brain proteins in regulating metal levels to maintain healthy function.

阿什利布什教授广泛研究了金属生物化学对阿尔茨海默病和帕金森病的贡献。在目前的提案中，他将领导一种新药的临床测试，该药物可对抗阿尔茨海默氏症脑部病理中金属的异常积累，他将寻找与血液蛋白的异常金属相互作用作为潜在的预测测试，他将研究各种脑蛋白的作用在调节金属水平以维持健康功能方面。