Chiral NMR Shift Reagents

这项研究得到了分析和表面的支持， 化学系的化学课程，旨在扩大 使用磁共振波谱来阐明 手性或手性的两种重要类型的分子： 环糊精（具有空腔的分子， 螯合其他特定大小和形状的分子）， 3，5-二硝基苯甲酰基氨基酸酯（氨基酸衍生物 用于分离不同手性的分子）。 镧系离子将结合到手性物质上。 附近 镧系元素对被探测分子的磁共振 光谱;量化的变化将导致的方法 用于分配手性。 %%% 这项研究得到了分析和表面的支持， 化学系的化学课程，旨在扩大 镧系元素NMR位移试剂用于探测手性的用途。 环糊精和3，5-二硝基苯甲酰氨基乙酸酯都将 用络合或共价结合的镧系元素进行研究， 顺磁位移物种。 绝对值的赋值 构型和手性相互作用的研究是主要的 这项研究的目标。

This research, supported by the Analytical and Surface Chemistry Program in the Division of Chemistry, seeks to expand the use of Magnetic Resonance Spectroscopy to elucidate the handedness or chirality of two important types of molecules: cyclodextrins (molecules with cavities that can selectively sequester other molecules of specific size and shape) and 3,5-dinitrobenzoylamino acid esters (derivatives of amino acids useful in separating molecules of different chirality). Lanthanide ions will be bound to chiral species. Proximity of lanthanides to probed molecules shifts their magnetic resonance spectra; quantification of the shifts will lead to the methods for assigning chirality. %%% This research, supported by the Analytical and Surface Chemistry Program in the Division of Chemistry, seeks to expand the use of lanthanide NMR shift reagents for probing chirality. Both cyclodextrins and 3,5-dinitrobenzoylamino aicd esters will be studied with complexed or covalently bound lanthanides as paramagnetic shift species. Assignment of absolute configuration and study of chiral interactions are primary goals of this research.