Chiral NMR Shift Reagents

贝茨学院的Thomas Wenzel教授得到了分析和表面化学计划的支持，继续致力于将大环主体与稀土移位试剂相结合，以使用核磁共振光谱(NMR)获得有关分析物的手性信息。确定某些化合物的独特绝对构型对于制药和其他生化工业是极其重要的。虽然核磁共振在本质上对分子的左旋性不敏感，但它可以用于这种分析应用中，与提供环境的大环相结合，从而能够确定准确的三维结构。在这个项目中，本科生接受关于工业相关主题的合成和核磁共振方法的培训。

Professor Thomas Wenzel of Bates College is supported by the Analytical and Surface Chemistry program to continue work on combining macrocyclic hosts with lanthanide shift reagents to obtain chiral information about analytes using Nuclear Magnetic Resonance spectroscopy (NMR). Determination of the unique absolute configurations of certain chemical compounds is extremely important for pharmaceutical and other biochemical industries. While NMR is not inherently sensitive to the handedness of molecules, it can be used in this analytical application in combination with macrocycles that provide environments enabling the exact three dimensional structures to be determined. In this project, undergraduate students receive training in synthesis and NMR methods on an industrially relevant topic.