Chiral NMR Shift Reagents

手性 NMR 位移试剂

• 批准号: 1145061
• 负责人: Thomas Wenzel
• 金额: $ 15.92万
• 依托单位: Bates College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1145061&HistoricalAwards=false
• 关键词: Chiral; NMR; Shift; Reagents

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Thomas Wenzel of Bates College and his undergraduate student researchers will be supported to synthesize and characterize new kinds of chiral NMR shift reagents. The kinds of reagents that Prof. Wenzel and his students create will enable chemists to rapidly determine the enantiomeric purity of newly synthesized compounds.Chiral molecules are molecules that have "handed" symmetry. They differ in structure from each other only in the sense that they are mirror images of each other. Since they have identical chemical structures, except for their handedness, it is difficult or impossible to use analytical techniques like NMR to assess the enantiomeric purity of mixtures of these compounds. Professor Wenzel and his students are interested in designing reagents that will interact with different optical isomers to different extent, which will cause differences in the NMR spectra for the different isomers. This work has important applications in the analysis of pharmaceuticals. The undergraduate students working on this project will gain useful experience in carrying out the physico-chemical characterization of these interesting molecules, and they will be prepared for further study in the chemical sciences.

该奖项由化学系化学测量和成像项目资助，贝茨学院的托马斯温泽尔教授和他的本科生研究人员将获得支持，以合成和表征新型手性NMR位移试剂。 Wenzel教授和他的学生创造的试剂将使化学家能够快速测定新合成化合物的对映体纯度。手性分子是具有“手”对称性的分子。 它们在结构上彼此不同，只是因为它们是彼此的镜像。 由于它们具有相同的化学结构，除了它们的手性之外，很难或不可能使用分析技术如NMR来评估这些化合物的混合物的对映体纯度。 Wenzel教授和他的学生们对设计试剂感兴趣，这些试剂将与不同的光学异构体在不同程度上相互作用，这将导致不同异构体的NMR光谱的差异。 这项工作在药物分析中有重要的应用。 从事该项目的本科生将获得对这些有趣分子进行物理化学表征的有用经验，并为进一步研究化学科学做好准备。