Chiral NMR Shift Reagents

这项本科院校的研究项目得到了分析和表面化学计划的支持，主要研究由顺磁性稀土离子与手性拆分剂偶联形成的手性核磁共振移动剂的制备和表征。托马斯·J·温泽尔教授和他在贝茨学院的本科生将把这项工作的结果与已知的光学异构体的色谱保留数据结合起来，这样就可以根据解析的核磁共振光谱来指定对映体的绝对构型。这项工作在制药工业和磁共振成像试剂领域具有应用价值。可以直接测定光学异构体构型的方法将由温泽尔教授和他在贝茨学院的本科生开发。将准备与光学异构体相互作用的试剂，以导致可分辨的核磁共振光谱。了解这些试剂是如何改变核磁共振光谱的，将允许对光学异构体进行构型分配。这项工作在药物化学和磁共振成像领域具有潜在的应用前景。

This Research at Undergraduate Institutions project, supported in the Analytical and Surface Chemistry Program, focusses on the preparation and characterization of chiral nuclear magnetic resonance shift reagents formed by coupling paramagnetic lanthanide ions with chiral resolving agents. Professor Thomas J. Wenzel and his undergraduate students at Bates College will combine the results from this work with known chromatographic retention data for optical isomers so that the assignment of the absolute configuration of enantiomers can be made from resolved nuclear magnetic resonance spectra. This work has application in the areas of the pharmaceutical industry and in magnetic resonance imaging reagents. Methods that permit the direct determination of the configuration of optical isomers will be developed by Professor Wenzel and his undergraduate students at Bates College. Reagents will be prepared that interact with optical isomers in a way that leads to resolved nuclear magnetic resonance spectra. Knowing how these reagents shift nuclear magnetic resonance spectra will permit the assignment of configuration to the optical isomers. This work has potential for application in pharmaceutical chemistry and in the are of magnetic resonance imaging.