Chiral NMR Shift Reagents

本项目由分析与表面化学项目资助，主要研究顺磁性镧系离子与手性溶解剂偶联形成的手性核磁共振移位试剂的制备和表征。Thomas J. Wenzel教授和他在贝茨学院的本科生将把这项工作的结果与已知的光学异构体的色谱保留数据结合起来，这样对映体的绝对构型的分配就可以从核磁共振光谱中得到。这项工作在制药工业和磁共振成像试剂领域有应用。直接测定光学异构体构型的方法将由温泽尔教授和他在贝茨学院的本科生开发。将制备与光学异构体相互作用的试剂，以一种导致核磁共振光谱分辨的方式。知道这些试剂如何移动核磁共振波谱将允许分配构型的光学异构体。这项工作在药物化学和磁共振成像领域具有潜在的应用前景。

This Research at Undergraduate Institutions project, supported in the Analytical and Surface Chemistry Program, focusses on the preparation and characterization of chiral nuclear magnetic resonance shift reagents formed by coupling paramagnetic lanthanide ions with chiral resolving agents. Professor Thomas J. Wenzel and his undergraduate students at Bates College will combine the results from this work with known chromatographic retention data for optical isomers so that the assignment of the absolute configuration of enantiomers can be made from resolved nuclear magnetic resonance spectra. This work has application in the areas of the pharmaceutical industry and in magnetic resonance imaging reagents. Methods that permit the direct determination of the configuration of optical isomers will be developed by Professor Wenzel and his undergraduate students at Bates College. Reagents will be prepared that interact with optical isomers in a way that leads to resolved nuclear magnetic resonance spectra. Knowing how these reagents shift nuclear magnetic resonance spectra will permit the assignment of configuration to the optical isomers. This work has potential for application in pharmaceutical chemistry and in the are of magnetic resonance imaging.