Chiral NMR Shift Reagents

该研究项目由分析和表面化学项目支持，旨在开发利用核磁共振光谱（NMR）中镧系离子基化学位移试剂表征手性化合物的方法。环糊精用作手性络合剂，镧系螯合物与环糊精化学偶联。在核磁共振光谱中观察到化学位移，这取决于哪个对映体与环糊精络合。本研究解决了生物技术和制药研究中的一个重要问题。许多具有生理活性的药物只在一种配置下有效；化学性质相同的化合物的镜像可能完全无效。因此，能够确定合成过程中产生的这些镜像化合物（对映体）的混合物的组成是至关重要的。贝茨学院正在开发的基于磁共振波谱的方法可以区分两种对映体，也可以确定化合物的绝对构型。

This research project, supported by the Analytical and Surface Chemistry Program, seeks to develop methods for the characterization of chiral compounds using lanthanide ion based chemical shift reagents in nuclear magnetic resonance spectroscopy (NMR). Cyclodextrins are used as chiral complexing agents, and lanthanide chelates are chemically coupled to the cyclodextrins. Chemical shifts are observed in the NMR spectra which are dependent on which enantiomer is complexed by the cyclodextrin. This study addresses an important problem in biotechnology and pharmaceutical research. Many physiologically active drugs are only effective in one configuration; the chemically identical mirror image of the compound may be totally ineffective. It is therefore critical to be able to determine the composition of mixtures of these mirror image compounds (enantiomers) that result from the synthetic procedure. The methodology based on magnetic resonance spectroscopy being developed at Bates College will allow two enantiomers to be distinguished, and may also allow the absolute configuration of the compounds to be determined.