Chiral NMR Shift Reagents

该研究项目由分析和表面化学 计划，旨在开发手性化合物的表征方法， 使用镧系元素离子基化学位移试剂的化合物 磁共振光谱（NMR）。 环糊精用作手性 络合剂和镧系元素螯合物化学偶联到 环糊精。 在NMR光谱中观察到化学位移， 这取决于哪种对映体被环糊精络合。 这项研究解决了生物技术中的一个重要问题， 药物研究。 许多生理活性药物仅 在一种配置中有效;化学上相同的镜像 该化合物可能完全无效。 因此， 能够确定这些镜像的混合物的组成 由合成过程产生的化合物（对映体）。 的 基于磁共振波谱学的方法学正在发展， 贝茨学院将允许区分两种对映异构体， 也允许确定化合物的绝对构型。

This research project, supported by the Analytical and Surface Chemistry Program, seeks to develop methods for the characterization of chiral compounds using lanthanide ion based chemical shift reagents in nuclear magnetic resonance spectroscopy (NMR). Cyclodextrins are used as chiral complexing agents, and lanthanide chelates are chemically coupled to the cyclodextrins. Chemical shifts are observed in the NMR spectra which are dependent on which enantiomer is complexed by the cyclodextrin. This study addresses an important problem in biotechnology and pharmaceutical research. Many physiologically active drugs are only effective in one configuration; the chemically identical mirror image of the compound may be totally ineffective. It is therefore critical to be able to determine the composition of mixtures of these mirror image compounds (enantiomers) that result from the synthetic procedure. The methodology based on magnetic resonance spectroscopy being developed at Bates College will allow two enantiomers to be distinguished, and may also allow the absolute configuration of the compounds to be determined.