Acquisition of an Analytical Ultracentrifuge

该部的一些研究项目 生物化学和生物物理学，俄勒冈州州立大学，取决于 关于使用分析沉淀法的问题。 这些 包括研究结构、稳定性和组装 染色质（K.E.货车霍尔德）：结构研究， 进化和血蓝蛋白的功能（K.I.米勒，K.E. 货车霍尔德）：酶之间关联的研究者 参与蛋白质磷酸化（S.R.安德森）;以及 参与DNA生物合成的多酶复合物 前体（C.K.马修斯）。 货车霍尔德博士的实验室 多年来一直维护并稳定使用Beckman 型号E。分析超浓缩 本仪器是 既过时又破旧 幸运的是， 研究，贝克曼仪器公司刚刚推出了 全新的超精密分析设计。 这一工具不仅能满足我们目前的需要， 部门，但将允许各种实验迄今 不可能的 该提案要求为这样一个项目提供资金， 仪器 作为一个一直在领导 超浓缩技术的利用和发展， 我们可以充分利用这一设施。

A number of research projects in the Department of Biochemistry and Biophysics, Oregon State University, depend on the use of analytical sedimentation methods. These include studies of the structure, stability, and assembly of chromatin (K.E. van Holde): studies of the structure, evolution, and function of hemocyanins (K.I. Miller, K.E. van Holde): investigators of association between enzymes involved in protein phosphorylation (S.R. Anderson); and multi-enzyme complexes involved in biosynthesis of DNA precursors (C.K. Mathews). The laboratory of Dr. van Holde has maintained, and steadily used for many years a Beckman Model E. analytical ultracentrifuge. This instrument is both obsolete and decrepit. Fortunately for our future research, the Beckman Instrument Company has just come out with a radically new analytical ultracentrifuge design. This instrument will not only meet the present needs of our department, but will allow kinds of experiments hitherto impossible. This proposal requests funds for such an instrument. As a group that has been a leader in the utilization and development of ultracentrifuge techniques, we are in a position to make maximum use of such a facility.