Mechanistic and Synthetic Studies of New Organic Transformations

本研究的重点是开发新的类 自由基反应机理和速率的研究。 酰基锗烷、硅烷和锡烷将作为 用于自由基加成、环化和成环的试剂。 芳基硒代丙二腈将在同一静脉开发， 特别重视1，2-不对称自由基的研究 反应. %%% 有了这个奖项，合成有机计划正在支持 医学系的丹尼斯·P·柯伦博士的研究 匹兹堡大学的化学系。 柯伦教授 他的工作将集中在有机自由基的理解上， 反应和发展新的转变， 添加到有用的激进反应的剧目。

The focus of this research is the development of new classes of radical reactions based on the study of mechanism and rate. Acyl germanes, silanes and stannanes will be developed as reagents for radical additions, cyclizations and annulations. Aryl selenomalonitriles will be developed in the same vein with a special emphasis on the study of 1,2-asymmetric radical reactions. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Dennis P. Curran of the Department of Chemistry at the University of Pittsburgh. Professor Curran will focus his work on the understanding of organic radical reactions and the development of new transformations which will add to the repertoire of preparatively useful radical reactions.